FBG biosensor is able to detect thrombin in human blood

FBG sensors for thrombin detectionThrombin plays a very important role in normal and pathological blood coagulation because its high level is an indication of tumor cell presence. Also, the level of thrombin is growing while atherosclerosis, thromboembolic disease, cancer, and inflammatory disease. Thus, its clinical importance provokes the development of devices for fast and precise thrombin detection and most of them are based on aptamers.

One of the ways to solve the problem is the use of optical-fiber grating-based sensors that have a great range of advantages:

  • high level of sensitivity;
  • multiplexing ability;
  • compact size;
  • lightweight;
  • possibility of multi-modal sensing;
  • tolerance to electromagnetic interference;
  • low manufacturing cost.

All FBG sensors are based on different operation principles. There are LPG, etched fiber Bragg gratings, tilted FBG, microstructured Bragg gratings, photonic crystal fibers, or PCF. Nowadays the development of these types of sensors, especially, those which can detect thrombin, is the primary objective.

Etched fiber Bragg grating (EFBG) is one of them, its manufacturing is highly simple and fast because it has chemical etching liquids (for example, hydrofluoric acid) that are able to take away the cladding very quick at a controlled rate. Also, EFBG differs from core-exposed micromachined gratings by the absence of a laser micromachining station that makes the process of fabrication harder.

In spite of the fact that etched fiber Bragg gratings sensors have less sensitivity than in other types, there are numerous advantages over these sensing devices. For example, EFBG systems obtain simple adjustability of their sensitivity. Moreover, there is no need for a polarization control because etched Bragg gratings measure reflection.

This optical-fiber grating-based sensing system operates with a wavelength of 1550 nm, uses hydrofluoric acid as etching fluid for approximately 27 minutes. It is able to detect thrombin in concentrations ranging from 10 nM to 80 nM and the use of EFBG has a promising future as the manufacture of FBG biosensors needs only chemical etching, also it is simple and less expensive than other types of sensing systems. Moreover, etching fiber Bragg grating sensors are easy for multiplexing and, consequently, can be used in vivo. Finally, all the advantages expand the opportunities for thrombin detection.

Optromix is a fiber Bragg grating (FBG) products manufacturer that offers FBG sensors, FBG interrogators and multiplexers, DAS systems, DTS systems. Optromix creates and supplies a broad variety of fiber optic solutions for monitoring worldwide. If you have questions or would like to buy FBG products, please contact us at info@optromix.com

Bioresorbable Fiber Bragg Grating sensor advances medicine

bioresosbable FBG sensorToday environmental change provokes the appearance of new diseases and, finally, human health care requirements continue increasing for several decades. Moreover, it is necessary to have new advanced tools for the disease diagnosis at early stages, for monitoring and treatment of patients. Then unconventional biomedical instrumentation and sensors, including optical-fiber sensors come for help to modern medicine. And devices with bioresorbable fiber sensors increase the efficiency of monitoring and treatment.

Fiber Bragg Grating (FBG) is one of the most productive ways suggested for fiber-based biomedical sensing. Fiber Bragg grating sensing technology provides a new and effective way of real-time measurements. The fields of FBGs application contain biosensing, safety or security, and structural-health monitoring. Also, FBG sensors are highly suitable for laser systems, medical tiny intra-aortic probes, and body sensors for biochemical analysis making.

Modern Fiber Bragg Gratings use bioresorbable optical-fiber sensing probes that have such ability as controlled solubility in a physiological environment. A bioresorbable material is the main component of FBG sensors and the human body easily and safely assimilates it at a special time interval. The technology allows safer diagnostic of sensitive human organs and there is no need for a surgical extraction. Fiber Bragg Gratings sensors are easy to install and use, their sensing points have quite high density. It is an ideal, cost-effective, and accurate technology for extreme environmental conditions.

The advantages of optical fiber include:

  • good mechanical durability;
  • high optical transmission;
  • stoichiometrically tunable dissolution rate.

It should be mentioned that tilted Bragg gratings with a 1-degree tilt angle that are immersed in phosphate-buffered saline solution with temperature and pH conditions similar to those of the human body allow fiber dissolution studying. Finally, selective chemical-etching effects were found out thanks to scanning electron microscope images and micro-Raman spectroscopy.

Thus, bioresorbable fiber Bragg grating sensors are considered to be effective for the development of soluble, compact photonic sensing probes that can be used for in vivo monitoring of vital mechanical or chemical factors with a specific time limit, and also in controlled in-body drug delivery.

Optromix is a fast-growing vendor of fiber Bragg grating (FBG) products line such as fiber Bragg grating sensors, FBG interrogators and multiplexers, Distributed Acoustic Sensing (DAS) systems, Distributed Temperature Sensing (DTS) systems. Optromix creates and supplies a broad variety of fiber optic solutions for monitoring worldwide. The range of services includes research programs, interpretation reports, layout design, system software modeling, commissioning, user training, real-time data transition, equipment supply, ground part installation, engineering, and technical support. If you have questions or would like to buy FBG products, please contact us at info@optromix.com

 

New Distributed Temperature Sensing allows fast oil extraction

DTS for oil extractionThe traditional methods of oil extraction become less and less productive despite growing human needs. Today the main challenge of the oil industry is the development of a new way for oil recovering from unconventional sources. The solution is the extraction of oil or kerogen shales that allow diminishing oil prices.

It is possible, because of the distributed temperature sensing (DTS) method that uses optical fiber cables, however, DTS with optical fibers using polymeric coatings becomes not efficient at temperatures exceeding 300°C, but optical fibers coated in gold withstand the temperature.

 

A conventional way of oil extraction includes drilling a well into a location underground, where oil flows freely from a reservoir. Also, oil can be removed using non-traditional methods. Thus, unconventional oils, for example, oil shale, are becoming more economically and technically accessible techniques thanks to absolutely new modern technologies.

Distributed temperature sensing becomes the main tool for unconventional oil recovering that makes the process more efficient with advanced methods, such as the measurement of the whole well system temperature. To be precise, it is possible for DTS to monitor the temperature at several points along the well, where optical fibers are used as the temperature sensor element.

Since the majority of DTS systems use optical fibers covered with polymeric coatings, their use is limited for temperatures up to 300 °C, because the fiber life expectancy is gradually reducing.

Such high temperatures of 350 °C are necessary for kerogen to oil conversion. So new distributed temperature sensing with optical fibers coated in gold is able to stand temperatures as high as 700 °C and identify hot spots that are highly important to regulating in-ground systems.

 

One of the main aims of the new DTS program is the actual well temperatures measurement. Moreover, continuously monitoring well temperatures is crucial for precisely controlling the amount and rate of heat applied because finally, this estimates the amount of oil that will be extracted at the time of the in-situ retort process.

Also distributed temperature sensor systems are used in numerous fields, for example, power cable monitoring, fire detection, leakage detection, industrial induction furnace surveillance, pipelines integrity surveillance, healthcare and biomedicine areas, etc. Nevertheless, the use of DTS systems in oil and gas production is the main factor driving the growth of the DTS market.   

Optromix is a DTS system manufacturer that provides top of the line distributed temperature sensing systems suitable for monitoring the underground power cable temperature profile. If you have any questions or would like to buy a DTS system, please contact us at info@optromix.com

Fiber Optic DAS helps to get rid of theft

DAS for theft detectionDistributed Acoustic Sensing (DAS) systems are based on fiber optic technology, which allows the systems to be used with extreme operating conditions, for example, extremely high or low temperatures, physical space limitations, unique measurement requirements, etc. DAS system consists of a distributed acoustic sensors that can be either mounted on the object or buried at a certain distance from it, In-cab InGound Stainless Steel Tube, and software that allows remote control and status monitoring.

The areas of DAS systems use include:

  • in-well monitoring for leakage detection and activity control;
  • perimeter security, for example, the security of a hotel;
  • vibroacoustic monitoring of oil wells that allows us to find out the points of columns and packers leakage, determinate the fluid’s inflow, and the hydraulic fracturing intervals.

 

Now Distributed Acoustic Sensing systems are the best way for the intrusion and disruption detection of overhead power lines to reduce theft cases and costs. Unfortunately, today power line theft and tampering remain a major problem all around the world. Also every year the industry loses billions of dollars only in electricity theft.

Theft and tampering within the energy supply sector is a serious problem because it creates energy supply breaks and operational losses for supply companies and national grids. Traditional methods of resolving the issue (whether due to power or metal theft) are extremely time-consuming, inefficient, and expensive. In the majority of cases, DAS is the only solution to the main obstacle that is detecting and identifying the occurrence of theft events.

The fiber optic DAS system is a cost-effective method to identify and reduce tampering levels. The fiber optic monitoring allows identifying tampering with overhead lighting and distribution poles that are connected via a fiber optic cable. Moreover, real-time identification of thefts and tampering with the help of fiber optic cables are already in place. DAS system detects any underlying disturbances because all the surrounding environmental noises are filtered out.

The advantages of fiber optic distributed acoustic sensing systems include:

  • Identification of the precise damage location;
  • Tampering information pass onto security systems for the immediate action;
  • Broadcast alert to the company via email or SMS.

Optromix is a fast-growing vendor of fiber Bragg grating (FBG) products line such as fiber Bragg grating sensors, FBG interrogators and multiplexers, Distributed Acoustic Sensing (DAS) systems, Distributed Temperature Sensing (DTS) systems. Optromix creates and supplies a broad variety of fiber optic solutions for monitoring worldwide. The range of services includes research programs, interpretation reports, layout design, system software modeling, commissioning, user training, real-time data transition, equipment supply, ground part installation, engineering, and technical support. If you are interested in DAS systems and want to learn more, please contact us at info@optromix.com